SPINAL-OM: A registry-embedded trial of antibiotic duration in SCI-associated pelvic osteomyelitis

Dr Gemma Reynolds, is one of the two recipients of the inaugural Marigold Southey and Freemasons Foundation Victoria Spinal Cord Injury Research Grant.

About the study

People living with spinal cord injury (SCI) frequently develop pressure injuries, which can lead to serious bone infections (osteomyelitis). These infections often require long hospital stays, surgery, and weeks of antibiotics. However, the optimal duration of antibiotic treatment is unknown, and current practice is based largely on tradition rather than evidence.

This study will test whether a shorter course of antibiotics (4 weeks) is as safe and effective as the standard longer course (6 weeks) after surgery. It will be conducted within the Victorian Spinal Cord Service and embedded in a real-world clinical registry, allowing us to follow patients over time and understand outcomes both in hospital and after discharge.

Objectives

By reducing unnecessary antibiotic exposure, this study aims to improve recovery, reduce side effects, shorten hospital stays, and support earlier return to independence. The findings will directly inform clinical care and future national guidelines for managing infections in people with SCI.